研究業績

 

  1. K. Inoue, D. Hosaka, N. Mochizuki, H. Akatsu, K. Tsutsumiuchi, Y. Hashizume, N. Matsukawa, T. Yamamoto, T. Toyo'oka, Simultaneous Determination of Post-Translational Racemization and Isomerization of N‑Terminal Amyloid‑β in Alzheimer’s Brain Tissues by Covalent Chiral Derivatized Ultraperformance Liquid Chromatography Tandem Mass Spectrometry, Analytical Chemistry, 86 (1), 797-804 (2014).

  2. H. Takahashi, R. Nakayama, S. Hayashi, T. Nemoto, Y. Murase, K. Nomura, T. Takahashi, K. Kubo, S. Marui, K. Yasuhara, T. Nakamura, T. Sueno, A. Takahashi, K. Tsutsumiuchi, T. Ohta, A. Kawai, S. Sugita, S. Yamamoto, T. Honda, T. Yoshida, T. Hasegawa, Macrophage Migration Inhibitory Factor and Stearoyl-CoA Desaturase 1: Potential Prognostic Markers for Soft Tissue Sarcomas Based on Bioinformatics Analyses, PLoS One, 8 (10), e78250 (2013).

  3. 山城 舞, 杉村俊英, 小林 猛, 堤内 要, N-ビニル-2-ピロリドン/メタクリル酸メチル/メタクリル酸三元共重合体被覆マグネタイトナノ粒子の調製と特性解析, 高分子論文集, 69 (7), 392-398 (2012).

  4. K. Inoue, A. Ikemura, Y. Tsuruta, K. Tsutsumiuchi, T. Hino, and H. Oka, On-line solid phase extraction LC-MS/MS for the determination of Ac-SDKP peptide in human plasma from hemodialysis patients, Biomedical Chromatography, 26 (2), 137-141 (2012).

  5. K. Tsutsumiuchi, Y. Watanabe, M. Watanabe, M. Hibino, M. Kambe, N. Okajima, H. Negishi, J. Miwa, and H. Taniguchi, Formation of acrylamide from glucans and asparagine, New Biotechnology, 28 (6), 566-573 (2011).

  6. K. Inoue, A. Ikemura, Y. Tsuruta, K. Watanabe, K. Tsutsumiuchi, T. Hino, and H. Oka, Quantification of N-acetyl-seryl-aspartyl-lysyl-proline in hemodialysis patients administered angiotensin-converting enzyme inhibitors by stable isotope dilution liquid chromatography–tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 54 (4), 765-771 (2011).

  7. K. Inoue, Y. Ito, Y. Hattori, K. Tsutsumiuchi, S. Ito, T. Hino, H. Oka, Efficient purification of xanthomonasin A and B from Monascus yellow colorant by high-speed countercurrent chromatography, Japanese Journal of Food Chemistry and Safety, 17 (3), 185-191 (2010).

  8. K. Hasegawa, S. Miwa, K. Tsutsumiuchi, J. Miwa, Allyl Isothiocyanate That Induces GST and UGT Expression Confers Oxidative Stress Resistance on C. elegans, as Demonstrated by Nematode Biosensor, PLoS ONE, 5 (2), e9267 (2010).

  9. 堤内 要, アクリルアミド, 食品安全の事典, 日本食品衛生学会編集, 朝倉書店, 2009, p.229-231.

  10. K. Inoue, Y. Mizuno, Y. Yoshimi, M. Nunome, T. Hino, K. Tsutsumiuchi, H. Oka, Determination of avoparcin in animal tissues and milk using LC-ESI-MS/MS and tandem-SPE, Journal of Separation Science, 31 (22), 3871-3878 (2008).

  11. K. Inoue, C. Nomura, Y. Mizuno, Y. Yoshimi, K. Tsutsumiuchi, T. Hino, H. Oka, Separation of Major Safflowers from Carthamus Yellow using High-Speed Countercurrent Chromatography, Journal of Liquid Chromatography & Related Technologies, 31 (7), 1047-1059 (2008).

  12. K. Hasegawa, S. Miwa, K. Isomura, K. Tsutsumiuchi, H. Taniguchi, J. Miwa, Acrylamide-Responsive Genes in the Nematode Caenorhabditis elegans, Toxicological Sciences, 101 (2), 215-225 (2008).

  13. K. Hasegawa, S. Miwa, T. Tajima, K. Tsutsumiuchi, H. Taniguchi, J. Miwa, A Rapid Inexpensive Method to Screen for Common Foods That Reduce the Action of Acrylamide, a Harmful Substance in Food, Toxicology Letters, 175 (1-3), 82-88 (2007).

  14. 堤内 要, 神戸真理子, 岡嶋直子, 高村基治, 岡田鉦彦, 三輪錠司, 谷口 肇, 食品中のアクリルアミド, 生物機能開発研究所紀要(中部大学), 7, 7-12 (2007).

  15. 堤内 要, 加工食品中のアクリルアミドモノマーの低減化法について, 食品衛生学雑誌, 46 (6), J-335-J-337 (2005).

  16. K. Tsutsumiuchi, M. Hibino, M. Kambe, N. Okajima, M. Okada, J. Miwa, and H. Taniguchi, Effect of Carbohydrates on Formation of Acrylamide in Cooked Food Models, Journal of Applied Glycoscience, 52 (3), 219-224 (2005).

  17. K. Hasegawa, S. Miwa, K. Tsutsumiuchi, H. Taniguchi, and J. Miwa, Extremely Low Dose of Acrylamide Decreases Lifespan in Caenorhabditis elegans, Toxicology Letters, 152 (2), 183-189 (2004).

  18. 堤内 要, アリル 3-O-アリル-6-O-(p-メトキシフェニル)-D-グルコピラノシドの合成, 中部大学応用生物学部紀要, 3, 5-8 (2004).

  19. K. Tsutsumiuchi, M. Hibino, M. Kambe, K. Oishi, M. Okada, J. Miwa, and H. Taniguchi, Application of Ion-trap LC/MS/MS for Determination of Acrylamide in Processed Foods, Journal of the Food Hygienics Society of Japan, 45 (2), 95-99 (2004).

  20. K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, M. Furusaka, and M. Nagao, Small-Angle Neutron Scattering Investigations of Layer-Block Dendrimers in Aqueous Solutions, The Journal of Physical Chemistry B, 107 (7), 1532-1539 (2003).

  21. K. Funayama, T. Imae, H. Seto, K. Aoi, K. Tsutsumiuchi, M. Okada, M. Nagao, and M. Furusaka, Fast and Slow Dynamics of Water-Soluble Dendrimers Consisting of Amido-Amine Repeating Units by Neutron Spin-Echo, The Journal of Physical Chemistry B, 107 (6), 1353-1359 (2003).

  22. M. Ito, T. Imae, K. Aoi, K. Tsutsumiuchi, H. Noda, and M. Okada, In Situ Investigation of Adlayer Formation and Adsorption Kinetics of Amphiphilic Surface-Block Dendrimers on Solid Substrates, Langmuir, 18 (25), 9757-9764 (2002).

  23. 青井啓悟, 勝部宗夫, 堤内 要, 岡田鉦彦, 星型デンドリマーに基づくナノ構造体の精密構築, 高分子論文集, 59 (12), 742-752 (2002).

  24. K. Tsutsumiuchi, Improved Synthesis of 3-O-Acetyl-2,4,6-Tri-O-Benzyl-α-D-Glucopyranosyl Chloride from Allyl 3-O-Allyl-2,4,6-Tri-O-Benzyl-D-Glucopyranoside, Annual Report of Research Institute for Biological Function (Chubu University), 2, 17-20 (2002).

  25. K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, H. Seto, and M. Nagao, Characterizations of Sugar Ball in Solution by SANS and NSE, Journal of Physical Society Japan, 70 (Supplement A), 326-328 (2001).

  26. K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, and H. Seto, Dynamics of Poly(amido amine) Dendrimer in Aqueous Solutions, Activity Report on Neutron Scattering Research, 2000, 266 (2001).

  27. K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, and M. Nagao, Conformation of Sugar Ball in Aqueous Solutions, Activity Report on Neutron Scattering Research, 2000, 261 (2001).

  28. T. Imae, M. Ito, K. Aoi, K. Tsutsumiuchi, H. Noda, and M. Okada, Formation of Organaized Adsorption Layers by Amphiphilic Dendrimers, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 175 (1-2), 225-234 (2000).

  29. K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, and M. Furusaka, Segment Density Profiles in Dendrimers by SANS Analysis, KENS Report, 12, 219-220 (2000).

  30. K. Aoi,T. Hatanaka, K. Tsutsumiuchi, M. Okada, and T. Imae, SANS Analysis of a Novel Star-Shaped Dendrimer, KENS Report, 12, 217-218 (2000).

  31. M. Okada, K. Aoi, and K. Tsutsumiuchi, "Syntheses and Functions of Glycopeptide Surface-Modified Dendrimers" in Tailored Polymers & Applications, Y. Yagci, M. K. Mishra, O. Nuyken, K. Ito, and G. Wnek, Eds., VSP, Zeist, 2000, p.85 - 96.

  32. K. Tsutsumiuchi, K. Aoi, and M. Okada, Ion Complex Formation between Poly(amido amine) Dendrimer HCI Salt and Poly(L-glutamic acid) Sodium Salt, Polymer Journal, 32 (2), 107-112 (2000).

  33. K. Aoi, A. Motoda, M. Ohno, K. Tsutsumiuchi, M. Okada, and T. Imae, Synthesis and Assembly of Amphiphilic Tadpole-Shaped Block Copolymers Based on Poly(amido amine) Dendrimer, Polymer Journal, 31 (11-2), 1071-1078 (1999).

  34. K. Tsutsumiuchi, K. Aoi, and M. Okada, Globular Carbohydrate Macromolecule" Sugar Balls" 4. Synthesis of Dendritic Nanocapsules with Molecular Recognition Sites on Periphery, Polymer Journal, 31 (11-1), 935-941 (1999).

  35. K. Aoi, T. Hatanaka, K. Tsutsumiuchi, M, Okada, and T. Imae, Synthesis of a Novel Star-Shaped Dendrimer by Radial-Growth Polymerization of Sarcosine Ν-Carboxyanhydride Initiated with Poly(trimethyleneimine) Dendrimer, Macromolecular Rapid Communication, 20 (7), 378-382 (1999).

  36. T. Imae, K. Funayama, K. Aoi, K. Tsutsumiuchi, M. Okada, M. Furusaka, Small-Angle Neutron Scattering and Surface Force Investigations of Poly(amido amine) Dendrimer with Hydroxyl End Groups, Langmuir, 15 (12), 4076-4084 (1999).

  37. T. Imae, K. Funayama, K. Aoi, K. Tsutsumiuchi, and M. Okada, Intermolecular Interaction and Adsorption Properties of Poly(amido amine) Dendrimer with OH-Terminal, Proceedings of Yamada Conference L Polyelectrolytes, 439-442 (1999).

  38. K. Aoi, K. Tsutsumiuchi, A. Yamamoto, and M. Okada, Globular Carbohydrate Macromolecule "Sugar Balls" 2. Synthesis of Mono(glycopeptide)-Persubstituted Dendrimers by Polymer Reaction with Sugar-Substituted α-Amino Acid Ν-Carboxyanhydrides (glycoNCAs), Macromolecular Rapid Communication, 19 (1), 5-9 (1998).

  39. M. Okada, K. Aoi, and K. Tsutsumiuchi, Synthesis of Glycopeptide Conjugates via Ring-Opening Polymerization of Sugar-Substituted α-Amino Acid Ν-Carboxyanhydrides (GlycoNCAs), Proceedings of the Japan Academy, 73 (10), 205-209 (1997).

  40. 青井啓悟, 堤内 要, 岡田鉦彦, 複合糖質高分子の精密構築. シュガーボールとリビング糖ペプチド, 高分子論文集, 54 (10), 649-660 (1997).

  41. K. Aoi, K. Tsutsumiuchi, A. Yamamoto, and M. Okada, Globular Carbohydrate Macromolecule "Sugar Balls" 3. "Radial-Growth Polymerization"of Sugar-Substituted α-Amino Acid Ν-Carboxyanhydrides (GlycoNCAs) with a Dendritic Initiator, Tetrahedron, 53 (45), 15415-15427 (1997).

  42. K. Tsutsumiuchi, K. Aoi, and M. Okada, Synthesis of Polyoxazoline-(Glyco)peptide Block Copolymers by Ring-Opening Polymerization of (Sugar-Substituted) α-Amino Acid Ν-Carboxyanhydrides with Polyoxazoline Macroinitiators, Macromolecules, 30 (14), 4013-4017 (1997).

  43. K. Naka, R. Yamashita, T. Nakamura, A. Ohki, S. Maeda, K. Aoi, K. Tsutsumiuchi, and M. Okada, Aggregates of Peptide Containing Block Copolymers and Their Interactions with a Lipase in Aqueous Solution, Macromolecular Chemistry and Physics, 198 (1), 89-100 (1997).

  44. K. Aoi, K. Tsutsumiuchi, E. Aoki, and M. Okada, First Synthesis of Glycopeptide Macromonomers and Graft-Type Sugar-Containing Polymers with Glycopeptide Side Chains, Macromolecules, 29 (12), 4456-4458 (1996).

  45. K Naka, R. Yamashita, T. Nakamura, A. Ohki, S. Maeda, K. Aoi, K. Tsutsumiuchi, and M. Okada, Aggregate of a Peptide-Containing Block Copolymer with a Lipase, Macromolecular Rapid Communication, 17 (4), 269-274 (1996).

  46. K. Aoi, K. Tsutsumiuchi, and M. Okada, Synthesis of Novel Glycopeptide-Polyoxazoline Block Copolymers by Direct Coupling between Living Anionic and Cationic Polymerization Systems, Macromolecular Rapid Communication, 16 (10), 749-755 (1995).

  47. K. Aoi, K. Tsutsumiuchi, and M. Okada, Glycopeptide Synthesis by an α-Amino Acid Ν-Carboxyanhydride (NCA) Method: Ring-Opening Polymerization of a Sugar-Substituted NCA, Macromolecules, 27 (3), 875-877 (1994).


その他

  1. 堤内 要, “7章 化学反応:エネルギー, 速度および平衡”, 第4版 マクマリー生物有機化学 基礎化学編, 丸善, pp.188-225 (2015).

  2. 堤内 要, “7章 化学反応:エネルギー, 速度および平衡”, 第2版 マクマリー生物有機化学 基礎化学編, 丸善, pp.189-215 (2007).

  3. 堤内要, 学生ノートパソコンを活用した授業の実践報告 -応用生物学部『有機化学』の場合-, 中部大学教育研究, 5, 113-118 (2006).