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町田 千代子
小林 猛
根岸 晴夫
山木 昭平
坂野 弘美
小島 晶子
高橋 広夫
松本 省吾
榊原 均
エンダン
セミアルティ
お問い合せ
中部大学
応用生物学部
生物機能開発研究所
植物バイオ研究センター
ヘルスサイエンスヒルズ
小林 猛 中部大学・応用生物学部・応用生物化学科・教授
  1. Honda, H. and Kobayashi, T. : Fuzzy control of bioprocess, in japan, Biotechnology Annual Review, 5(1), 1-23(2000)
  2. Noguchi, H., Hanai, T., Honda, H., Harrison, L. C. and Kobayashi, T. : Fuzzy neural network-based prediction of motif for MHC class ÖァEbinding peptides, J. Biosci. Bioeng., 92(3), 227-231(2001)
  3. Tomita, S., Hanai, T., Koma, N., Honda, H., Suzuki, Y. and Kobayashi, T. : Artificial neural network predictive model for allergic disease using single nucleotide polymorphisms data, J. Biosci. Bioeng., 93(5), 470-478(2002)
  4. Tomita, S., Hanai, T., Honda, H. and Kobayashi, T. : Analysis of expression profile using fuzzy adaptive resonance theory, Bioinformatics, 18(8), 1073-1083(2002)
  5. Noguchi, H., Kato, R., Hanai, T., Matsubara, Y., Honda, H., Brusic, V. and Kobayashi, T. : Hidden Markov model-based prediction of antigenic peptides that interact with MHC class II molecules, J. Biosci. Bioeng., 94(3), 264-270 (2002)
  6. Ando, T., Suguro, M., Hanai, T., Kobayashi, T., Honda, H. and Seto, M. : Fuzzy neural network applied to gene expression for prognosis of diffuse large B-cell lymphoma, Jpn. J. Cancer Res., 93(11), 1207-1212(2002)
  7. Hayashi, S., Aono, R., Hanai, T., Mori, H., Kobayashi, T. and Honda, H. : Analysis of organic solvent tolerancy using gene expression profiles from Escherichia coli DNA microarray, J. Biosci. Bioeng., 95(4), 379-383(2003)
  8. Hanai, T., Yatabe, Y., Nakayama, Y., Takahashi, T., Honda, H., Mitsudomi, T. and Kobayashi, T. : Prognostic models in patients with non-small-cell lung cancer using artificial neural networks in comparison with logistic regression, Cancer Science, 94(5), 473-477(2003)
  9. Hanai, T., Ohki, T., Honda, H. and Kobayashi, T. : Analysis of initial conditions for polymerization reaction using fuzzy neural network and genetic algorithm, Computers and Chemical Engineering, 27, 1011-1019(2003)
  10. Kato, N., Kobayashi, T. and Honda, H. : Screening of stress enhancer based on analysis of gene expression profiles: Enhancement of hyperthermia-induced tumor necrosis by a MMP-3 inhibitor, Cancer Science, 94(7), 644-649(2003)
  11. Liu, X., Hibino, S., Hanai, T., Imanishi, T., Shirataki, T., Ogawa, T., Honda, H. and Kobayashi, T. : Construction of an electro-encephalogram-based brain computer interface with artificial neural networks, IEICE Transactions on Information and Systems, E86-D(9), 478-486 (2003)
  12. Takahashi, H., Tomita, S., Kobayashi, T. and Honda, H. : Inference on common genetic network using Fuzzy ART associated matrix method, J. Biosci. Bioeng., 96(2), 154-160(2003)
  13. Ando, T., Suguro, M., Seto, M., Kobayashi, T. and Honda, H. : Selection of casual gene sets for lymphoma prognostication from expression profiling and construction of prognostic fuzzy neural network models, J. Biosci. Bioeng., 96(2), 161-167 (2003)
  14. Kato, R., Noguchi, H., Honda, H. and Kobayashi, T. : Hidden Markov model-based approach as the first screening of binding peptides that interact with MHC class II molecules, Enzyme and Microbial Technology, 33(4), 472-481 (2003)
  15. Ando, T., Suguro, M., Kobayashi, T., Seto, M. and Honda, H. : Multiple fuzzy neural network system for outcome prediction and classification of 220 lymphoma patients from molecular profiling, Cancer Science, 94(10), 906-913(2003)
  16. Kato, R., Kunimatsu, M., Fujimoto, S., Kobayashi, T. and Honda, H. : Angiotensin II inhibitory peptide found in the receptor sequence using peptide array, Biochemical Biophysical Research Communication, 315(1), 22-29(2004)
  17. Liu, X., Hibino, S., Hasegawa, Y., Hanai, T., Mitsushima, T., Iida, A., Matsubara, M., Honda, H. and Kobayashi, T. : Evaluation of the Alzheimer type-dementia by magnetic resonance imaging using fuzzy neural networks, J. Chem. Eng. Jpn., 37(3), 429-435 (2004)
  18. Hanai, T., Iwata, N., Furuhashi, T., Honda H. and Kobayashi, T. : Proposal of reliablility index in search for reliable solutions of reversible calculation based on fuzzy neural network modeling, J. Chem. Eng. Jpn., 37(4), 523-530 (2004)
  19. Hakamada, K., Hanai, T., Honda, H. and Kobayashi, T. : A preprocessing method for inferring genetic interaction from gene expression data using Boolean algorithm, J. Biosci. Bioeng., 98(6), 457-463 (2004)
  20. Takahashi, H., Kobayashi T. and Honda, H. : Construction of robust prognostic predictors by using projective adaptive resonance theory as a gene filtering method, Bioinformatics, 21(2), 179-186 (2005)
  21. Shimizu, K., Hayashi, S., Kako, T., Suzuki, M., Tsukagoshi, N., Doukyu, N., Kobayashi, T. and Honda, H. : Discovery of glpC, an organic solvent Tolerance-Related gene in Escherichia coli, using gene expression profiles from DNA microarrays, Appl. Environ. Microbiol., 71(2), 1093-1096 (2005)
  22. Shimizu, K., Hayashi, S., Doukyu, N., Kobayashi, T. and Honda, H. : Time-course data analysis of gene expression profiles reveals purR regulon concerns in organic solvent tolerance in Escherichia coli, J. Biosci. Bioeng., 99(1), 72-74 (2005)
  23. Kim, S.-Y., Nishioka, M., Hayashi, S., Honda, H., Kobayashi, T. and Taya, M. : The gene yggE functions in restoring physiological defects of Escherichia coli cultivated under oxidative stress conditions, Appl. Environ. Microbiol., 71(5), 2762-2765 (2005)
  24. Mutoh, H., Hamajima, N., Tajima, K., Kobayashi, T. and Honda, H. : Exhaustive exploring using Artificial Neural Network for identification of SNPs combination related to Helicobacter pylori infection susceptibility, Chem-Bio Inform. J., 5(2), 15-26 (2005)
  25. Kato, R., Nakano, H., Konishi, H., Kato, K., Koga, Y., Yamane, T., Kobayashi, T. and Honda, H. : Novel strategy for protein exploration; High-throughput screening assisted with fuzzy neural network, J. Mol. Biol., 351, 683-692 (2005)
  26. Ito, A., Kobayashi, T. and Honda, H. : A mechanism of antitumor immunity induced by hyperthermia. Jpn. J. Hyperthermic Oncology, 21, 1-11 (2005)
  27. Hongo, T., Kajikawa, M., Ishida, S., Ozawa, S., Ohno, Y., Sawada, J., Umezawa, A., Ishikawa, Y., Kobayashi, T. and Honda, H. : Three-dimensional high-density culture of hepG2 cells in a 5-ml radial-flow bioreactor for construction of artificial liver. J. Biosci. Bioeng., 99, 237-244 (2005)
  28. Ito, A., Ino, K., Kobayashi, T. and Honda, H. : The effect of RGD peptide-conjugated magnetite cationic liposomes on cell growth and cell sheet harvesting Biomaterials, 26, 6185-6193(2005)
  29. Kawai, N., Ito, A., Nakahara, Y., Futakuchi, M., Shirai, T., Honda, H., Kobayashi, T. and Kohri, K. : Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats. The Prostate, 64, 373-381(2005)
  30. Tanaka, K., Ito, A., Kobayashi, T., Kawamura, T., Shimada,S., Matsumoto, K., Saida, T. and Honda, H. : Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles. Int. J. Cancer, 116, 624-633(2005)
  31. Tanaka, K., Ito, A., Kobayashi, T., Kawamura, T., Shimada, S., Matsumoto, K., Saida, T. and Honda, H. : Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma. J. Biosci. Bioeng., 100, 112-115(2005)
  32. Ito, A., Fujioka, M., Tanaka, K., Kobayashi, T. and Honda, H. : Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate. J. Biosci. Bioeng., 100, 36-42(2005)
  33. Ito, A., Hibino, E., Honda, H., Kobayashi, C., Terasaki, H., Kagami, H., Ueda, M. and Kobayashi, T. : Construction and delivery of tissue-engineering human retinal pigment epithelial cell sheets using magnetite nanoparticles and magnetic force. Tissue Engineering, 11, 489-496 (2005)
  34. Ito, A., Shinkai, M., Honda, H. and Kobayashi, T. : Medical application of functionalized magnetic nanoparticles. J. Biosci. Bioeng., 100, 1-11(2005)
  35. Ito, A., Nakahara, Y., Fujioka, M., Kobayashi, T., Takeda, K., Nakashima, I. and Honda, H. : Complete regression of hereditary melanoma in a mouse model by repeated hyperthermia using magnetite cationic liposomes. Jpn. J. Hyperthermic Oncology, 21, 139-149(2005)
  36. Ito, A., Hibino, E., Shimizu, K., Kobayashi, T., Yamada, Y., Hibi, H., Ueda, M. and Honda, H. : Magnetic force-based mesenchymal stem cell expansion using antibody-conjugated magnetoliposomes. J. Biomedical, Materials Research: Part B Applied Biomaterials, 75, 320-327(2005)
  37. Ito, A., Ino, K., Hayashida, M., Kobayashi, T., Matsunuma, H., Kagami, H., Ueda, M. and Honda, H. : Novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force. Tissue Engineering, 11, 1553-1561(2005)
  38. Ito, A., Honda, H. and Kobayashi, T. : Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concenpt of “heat-controlled necrosis” with heat shock protein expression. Cancer Immunology Immunotherapy, 55, 320-328(2006)
  39. Okochi, M., Nakanishi, M., Kato, R., Kobayashi, T. and Honda, H. : High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence. FEBS Letters, 580, 885-889(2006)
  40. Kato, R., Okuno, Y., Kaga, C., Kunimatsu, M., Kobayashi, T. and Honda, H. : Pentamer peptide from Fas antigen ligand inhibits tumor-growth with solid-bound form found by peptide array. J. Peptide Res., 66, 146-153 (2006)
  41. Kato, R., Kaga, C., Kunimatsu, M., Kobayashi, T. and Honda, H. : Peptide array-based interaction assay of solid-bound peptides and anchorage- dependant cells and its effectiveness in cell-adhesive peptide design. J. Biosci. Bioeng., 101, 485-495(2006)
  42. Kawai, N., Ito, A., Nakahara, Y., Honda, H., Kobayashi, T., Futakuchi, M., Shirai, T., Tozawa, K. and Kohri, K. : Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core. The Prostate, 66, 718-727(2006)
  43. Ikehara, Y., Niwa, T., Biao, L.,Kabata-Ikehara, S., Ohashi, N., Kobayashi, T., Shimizu, Y., Kojima, N. and Nakanishi, H. : A carbohydrate recognition・based drug delivery and controlled release system using intraperitoneal macrophages as a cellular vehicle. Cancer Research, 66, 8740-8748 (2006)
  44. Tomita, Y., Asano, H., Izawa, H., Yokota, M., Kobayashi, T. and Honda, H. : Classification method for predicting the development of myocardial infarction by using the interaction between genetic and environmental factors. IPSJ Transactions on bioinformatics, 47, 48-66(2006)
  45. Takahashi, H., Murase, Y., Kobayashi, T., Honda, H. : New cancer diagnosis modeling using boosting and projective adaptive resonance theory with improved reliable index. Biochem. Eng. J., 33(2), 100-109 (2007)
  46. Okochi, M., Nakagawa, I., Kobayashi, T., Hayashi, S., Furusaki, S. and Honda, H. : Enhanced activity of 3d-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reduction of steroids. J. Biotechnology, 128, 376-382(2007)
  47. 佐藤信雄,小塩高広,中尾幸子,高橋広夫,岩川秀和,小島晶子,町田千代子,小林 猛 : シロイヌナズナに対するDNAチップを用いた遺伝子発現データのクラスタリング手法の比較, 中部大学応用生物学部紀要, 6, in 1-10 (2007)
  48. H. Takahashi, H. Iwakawa, S. Nakao, T. Ojio, R. Morishita, S. Morikawa, Y. Machida, C. Machida, T. Kobayashi, "Knowledge-based Fuzzy Adaptive Resonance Theory and Its Application to the Analysis of Gene Expression in Plants.", J.Biosci. Bioeng. 106(6), 587-593 (2008)
  49. A. Ito, T. Kobayashi : Intracellular hyperthermia using magnetic nanoparticles: A novel method for hyperthermia clinical applications, Thermal Medicine, 24, 113-129 (2008)
  50. J. Motoyama, N. Yamashita, T. Morino, T. Kobayashi, H. Honda : Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles, BioMagnetic Research and Technology, 6, on line (2008),
    http://www.biomagres.com/content/6/1/2
  51. T. Kikumori, T. Kobayashi, M. Sawaki and T. Imai : Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes, Breast Cancer Research Treatment, on line (2008), PubMed 18311580
  52. J. Motoyama, T. Hakata, R. Kato, N. Yamashita, T. Morino, T. Kobayashi, H. Honda : Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy, BioMagnetic Research and Technology, on line (2008)
    http://www.biomagres.com/content/6/1/4
  53. T. Kikumori, T. Kobayashi, M. Sawaki and T. Imai, ”Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes”, Breast Cancer Research Treatment, 113, 435-441 (2009)
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